David J Nikolic-Paterson Selected Research

GS-444217

10/2018	ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
1/2018	ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis.
11/2015	ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice.

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David J Nikolic-Paterson Research Topics

Disease

45	Fibrosis (Cirrhosis) 01/2021 - 01/2004
26	Inflammation (Inflammations) 01/2021 - 09/2002
19	Glomerulonephritis 02/2018 - 07/2000
17	Kidney Diseases (Kidney Disease) 10/2020 - 06/2003
16	Proteinuria 10/2018 - 07/2000
9	Diabetic Nephropathies (Diabetic Nephropathy) 12/2019 - 01/2004
9	Nephritis 01/2019 - 01/2003
7	Acute Kidney Injury (Acute Renal Failure) 01/2021 - 09/2010
7	Chronic Renal Insufficiency 12/2020 - 09/2014
7	Albuminuria 01/2018 - 01/2004
6	Anti-Glomerular Basement Membrane Disease (Goodpasture's Syndrome) 02/2018 - 01/2003
4	IGA Glomerulonephritis (IGA Nephropathy) 01/2020 - 01/2008
3	Necrosis 12/2020 - 01/2014
3	Hypertrophy 01/2019 - 12/2008
3	Thrombosis (Thrombus) 01/2018 - 12/2011
3	Disease Progression 03/2016 - 04/2009
3	Hyperglycemia 02/2008 - 01/2004
3	Obesity 01/2006 - 01/2004
2	Balkan Nephropathy (Balkan Endemic Nephropathy) 10/2021 - 01/2021
2	Reperfusion Injury 01/2021 - 01/2016
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 02/2018 - 01/2016
2	Emphysema 02/2018 - 05/2012
2	Type 2 Diabetes Mellitus (MODY) 01/2006 - 06/2005
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2006 - 06/2005
1	Animal Disease Models 01/2022
1	Renal Insufficiency (Renal Failure) 01/2021
1	Lupus Nephritis 01/2021
1	Rupture 02/2018
1	Chronic Disease (Chronic Diseases) 01/2018

Drug/Important Bio-Agent (IBA)

17	CollagenIBA 01/2018 - 02/2004
13	p38 Mitogen-Activated Protein KinasesIBA 10/2020 - 02/2003
10	Phosphotransferases (Kinase)IBA 01/2021 - 01/2009
8	JNK Mitogen-Activated Protein KinasesIBA 01/2021 - 02/2007
8	antiglomerular basement membrane antibodyIBA 02/2018 - 01/2003
8	CytokinesIBA 09/2014 - 07/2000
7	Messenger RNA (mRNA)IBA 05/2012 - 02/2003
5	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 01/2020 - 11/2014
5	EnzymesIBA 02/2018 - 01/2002
5	Syk KinaseIBA 01/2018 - 12/2011
5	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2014 - 09/2002
4	SteroidsIBA 01/2021 - 07/2006
4	Matrix Metalloproteinases (MMPs)IBA 02/2018 - 12/2011
4	Streptozocin (Streptozotocin)FDA Link 01/2018 - 12/2004
4	Macrophage Migration-Inhibitory FactorsIBA 02/2014 - 01/2002
4	Immunoglobulin G (IgG)IBA 01/2014 - 01/2003
4	Transforming Growth Factor beta1 (TGF beta 1)IBA 09/2010 - 02/2004
3	aristolochic acid I (aristolochic acid)IBA 10/2021 - 03/2016
3	4- (9- (tetrahydrofuran- 3- yl))- 8- (2,4,6- trifluorophenylamino)- 9H- purin- 2- ylaminocyclohexan- 1- olIBA 01/2021 - 01/2011
3	MAP Kinase Kinase Kinase 5IBA 10/2020 - 01/2016
3	Pharmaceutical PreparationsIBA 01/2019 - 04/2008
3	GS-444217IBA 10/2018 - 11/2015
3	AlbuminsIBA 01/2018 - 02/2004
3	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016 - 01/2013
3	Protein Isoforms (Isoforms)IBA 01/2016 - 12/2003
3	Proteins (Proteins, Gene)FDA Link 01/2016 - 02/2004
3	AntigensIBA 11/2014 - 01/2003
3	Macrophage Colony-Stimulating FactorIBA 07/2011 - 09/2002
3	CC 401IBA 09/2010 - 02/2007
3	Transforming Growth Factor beta (TGF-beta)IBA 10/2009 - 10/2004
2	Cyclophilin AIBA 12/2020 - 05/2020
2	Cyclophilins (Cyclophilin)IBA 12/2020 - 01/2018
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 12/2019 - 10/2018
2	ChemokinesIBA 09/2019 - 01/2004
2	TOR Serine-Threonine KinasesIBA 01/2019 - 01/2014
2	Extracellular Matrix ProteinsIBA 02/2018 - 05/2012
2	Serum AlbuminIBA 01/2018 - 02/2004
2	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 10/2014 - 07/2006
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 10/2014 - 01/2004
2	resolvin D1IBA 01/2013 - 01/2013
2	LipidsIBA 01/2013 - 12/2012
2	Interleukin-10 (Interleukin 10)IBA 05/2012 - 02/2003
2	Transcription Factors (Transcription Factor)IBA 06/2011 - 07/2000
2	nephrinIBA 01/2011 - 11/2008
2	NPHS2 proteinIBA 01/2011 - 11/2008
2	Immunoglobulin A (IgA)IBA 01/2011 - 01/2002
2	Prednisolone (Predate)FDA LinkGeneric 01/2010 - 04/2008
2	GlucocorticoidsIBA 01/2010 - 12/2005
2	mizoribineIBA 01/2010 - 04/2008
2	Insulin (Novolin)FDA Link 04/2008 - 02/2008
2	Cell Adhesion MoleculesIBA 06/2005 - 07/2000
2	CreatinineIBA 12/2004 - 01/2004
2	Blood Glucose (Blood Sugar)IBA 12/2004 - 01/2004
1	Complement System Proteins (Complement)IBA 01/2022
1	CalcineurinIBA 12/2020
1	Biomarkers (Surrogate Marker)IBA 10/2020
1	Sirtuin 1IBA 01/2020
1	InflammasomesIBA 01/2020
1	Transcription Factor Brn-3AIBA 01/2020
1	ginsenoside M1IBA 01/2020
1	PAR-2 ReceptorIBA 09/2019
1	InterleukinsIBA 09/2019
1	LigandsIBA 09/2019
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 09/2019
1	Fibronectins (Fibronectin)IBA 09/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019
1	Peptide Hydrolases (Proteases)FDA Link 01/2019
1	Enalapril FDA LinkGeneric 10/2018
1	Pancreatic Elastase (Elastase)IBA 02/2018

Therapy/Procedure

8	Therapeutics 01/2019 - 01/2004